60 Journal of Medicine and The Person, June 2008, vol.6, number 2: 60-64 I NVITED PAPER eccentric of life in thalassemia patients after unrelated haematopoietic root jail cell transplanting QualitÃ della vita in pazienti talassemici dopo trapianto non correlato di cellule staminali emopoietiche Caocci Giovanni1, Pisu Salvatore2, La Nasa Giorgio1 1 Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Cattedra di Ematologia, UniversitÃ di Cagliari, Cagliari, Italy. 2 Cattedra di Medicina Legale, UniversitÃ di Cagliari, Cagliari, Italy Abstract thalassaemia major is a chronic, progressive hemoglobin disorder requiring life-long blood transfusion and iron chelation therapy for survival. Extensive ongoing medical c be in this pathology may have a considerable blow on the physical, psychosocial well-being and quality of life (QoL) of patients and their families. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the exclusively cure purchasable for thalassemia. Unfortunately, only a substantial minority of patients have an HLA matched bestower within the family. More than 70 percent of patients need to inquiry for an unrelated compatible sponsor in voluntary bestower registries worldwide.
The transplantation-related mortality risk of unrelated HSCT in adult thalassemia patients has been estimated to be about 30%. For this reason, patients without a family donor ar faced with the difficult choice between accepting the gimpy risks of radical treatment or putting aside their hopes of retrieval and continuing regular transfusion and iro n chelation therapy. This complex decisivene! ss-making single-valued function raises several social, psychological and ethical problems. The central ethical take up do of HSCT in a non-malignant disease can be close in in terms of a troth between cardinal fundamental principles of medical ethics: non-maleficence and almsgiving; the question arises as to who will be responsible for the decision and what criteria can be used to strike a honorable balance...If you want to posture a full essay, order it on our website: OrderCustomPaper.com
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