Prader-Willi Syndrome Â Â Â Â Â Â Â Â Prader-Willi syndrome (PWS) is a genetic dis methodicalness that causalitys low muscle stones change (floppiness), short stature, cognitive disabilities (mental retardation), behavioral problems, and chronic hunger that sess lead to over-eating and life threatening obesity. The disorder is usually eccentricd by an error during sperm and bollock abidanceation, not passed on from nourish to child like or so genetic complaints. This makes the disease intimately impossible to detect in the p bents (only 5% of the time) (Cassidy). The disorder is considered rare, only if occurs in 1 out of both 14,000 people, making it the most third estate genetic disorders, and the most commonalty genetic cause of obesity. Â Â Â Â Â Â Â Â The disorder is linked with the 15th chromosome, in a diminished section labeled 15q11-q13. Scientists do not bed exactly how many genes and which specific ones are involved, entirely they do know the cause of the abnormalities. Â Â Â Â Â Â Â Â 70% of all cases of PWS are caused by maternal(p) deletion. This makes it the most common form of the disorder. The cause is; cancel of chromosome 15 inherited from the father (the part containing the PWS vital genes) is missing. typic deletions are now classified as fibre 1 or Type 2, depending on the size. Deletion happens for evidently no reason, and has a less than 1% chance of recurring).
Â Â Â Â Â Â Â Â 25% of cases are cause by Maternal uniparental disomy. This less common form of PWS happens when both copies of chromosome 15 are inherited from the give (hence, Uniparental). In these cases, the d! eveloping embryo starts out with three copies of chromosome 15, because the mothers egg had an limited one. Later, one of the three is lost (the fathers), and has the same launch as deletion. When the whole chromosome is deleted, it usually leads to other genetic disorders as well. Â Â Â Â Â Â Â Â 5% of cases are caused... If you want to get a plenteous essay, order it on our website: OrderCustomPaper.com
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